Quantitative und morphologische untersuchungen der retinaentwicklung bei trisomie-19-mäusen

Dietrich E. Lorke, Elisabeth Engelmann

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To investigate the development of the retinal layers, the eyes of mice with trisomy 19 have been examined by light microscopy between the 2nd and 15th postnatal day.The diameter of the eye, thickness of the entire retina and both relative thickness and nuclear density of each of the retinal layers have been measured and compared to those of chromosomally balanced control animals. Malformations of the eye, alterations of cell morphology or disturbed lamination can not be observed. Retinal differentiation of trisomy 19 mice is delayed by approximately two days. The development of all cellular constituents, i.e., of both neuroectodermal and mesenchymal origin, is retarded accordingly. The eyes of trisomy 19 mice are of reduced size. The relative thickness of each retinal layer follows a normal growth pattern: there is no indication for a selective impairment ot the development of one particular layer. With the exception of the ganglion cell layer, nuclear densities of each retinal layer do not differ from those of control mice. The comparison of nuclear densities in the ganglion cell layer suggests that in trisomy 19 mice fewer postmitotic cells differentiate into mature retinal cells.

Original languageBritish English
Pages (from-to)56-65
Number of pages10
JournalCells Tissues Organs
Issue number1
StatePublished - 1988


  • Development
  • Mouse
  • Retinal layers
  • Trisomy 19


Dive into the research topics of 'Quantitative und morphologische untersuchungen der retinaentwicklung bei trisomie-19-mäusen'. Together they form a unique fingerprint.

Cite this