TY - JOUR
T1 - Prolactin binding sites in rat brain and liver
T2 - effects of long-term ovariectomy and ovarian steroids
AU - Mustafa, A.
AU - Nyberg, F.
AU - Bogdanovic, N.
AU - Islam, A.
AU - Suliman, I.
AU - Lindgren, U.
AU - Roos, P.
AU - Adem, A.
N1 - Funding Information:
ported by grants from Konung Gustaf Vs och Drotting Victorias Stiftelse; the Swedish Medical Research Council; Gamla Tj~inarinnor and Hans and Loo Oster-man's Fond; Stiftelsen Sigurd och Elsa Goljes Minne; Pharmacia and KI Fonder.
PY - 1995/11/24
Y1 - 1995/11/24
N2 - The effects of long-term ovariectomy on the levels of brain and liver lactogenic binding sites as well as plasma and liver prolactin (PRL) have been investigated in sham-operated and ovariectomized rats receiving either 17β estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX-V). The levels of lactogenic binding sites in the parietal and piriform cortices, amygdala, thalamus, hypothalamus, as well as in the liver were significantly decreased after long-term ovariectomy. Moreover, the levels of plasma and liver PRL were also significantly decreased. Exogenous estradiol and progesterone replacement restored the levels of lactogenic binding sites in the parietal cortex and hypothalamus as well as in the liver. However, plasma and liver PRL levels were significantly increased by estradiol but only restored by progesterone. These results suggest that ovarian steroids influence the levels of lactogenic binding sites and prolactin.
AB - The effects of long-term ovariectomy on the levels of brain and liver lactogenic binding sites as well as plasma and liver prolactin (PRL) have been investigated in sham-operated and ovariectomized rats receiving either 17β estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX-V). The levels of lactogenic binding sites in the parietal and piriform cortices, amygdala, thalamus, hypothalamus, as well as in the liver were significantly decreased after long-term ovariectomy. Moreover, the levels of plasma and liver PRL were also significantly decreased. Exogenous estradiol and progesterone replacement restored the levels of lactogenic binding sites in the parietal cortex and hypothalamus as well as in the liver. However, plasma and liver PRL levels were significantly increased by estradiol but only restored by progesterone. These results suggest that ovarian steroids influence the levels of lactogenic binding sites and prolactin.
KW - Lactogenic binding sites
KW - Long-term ovariectomy
KW - Ovarian steroids
KW - Prolactin
KW - Rat brain
KW - Receptor autoradiography
UR - http://www.scopus.com/inward/record.url?scp=0028875474&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)12106-E
DO - 10.1016/0304-3940(95)12106-E
M3 - Article
C2 - 9064606
AN - SCOPUS:0028875474
SN - 0304-3940
VL - 200
SP - 179
EP - 182
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -