@article{4d48f92def594b479690cd9959f6650e,
title = "Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering",
abstract = "Due to the limitations of bone autografts, we aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue engineering applications. We used a porous, cross-linked and slowly biodegradable fibrin/alginate scaffold originally developed in our laboratory for wound healing, throughout which deposits of calcium phosphate (CaP) were evenly incorporated using an established biomimetic method. Material characterisation revealed the porous nature and confirmed the deposition of CaP precursor phases throughout the scaffolds. MC3T3-E1 cells adhered to the scaffolds, proliferated, migrated and differentiated down the osteogenic pathway during the culture period. Chick chorioallantoic membrane (CAM) assay results showed that the scaffolds were pro-angiogenic and biocompatible. The work presented here gave useful insights into the potential of these pro-angiogenic and osteogenic scaffolds for bone tissue engineering and merits further research in a pre-clinical model prior to its clinical translation.",
keywords = "angiogenic, Bone tissue engineering, calcium phosphate, fibrin, osteogenic",
author = "Nupur Kohli and Vaibhav Sharma and Alodia Orera and Prasad Sawadkar and Nazanin Owji and Frost, {Oliver G.} and Bailey, {Russell J.} and Martyn Snow and Knowles, {Jonathan C.} and Blunn, {Gordon W.} and Elena Garc{\'i}a-Gareta",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Restoration of Appearance and Function Trust (UK, registered charity number 299811) charitable funds. Funding Information: The authors would like to thank Dr Fred Jones from MCA services for help with MIP analyses. Authors would also like to acknowledge the use of Servicio General de Apoyo a la Investigaci?n-SAI, Universidad de Zaragoza (Spain). The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Restoration of Appearance and Function Trust (UK, registered charity number 299811) charitable funds. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
doi = "10.1177/20417314211005610",
language = "British English",
volume = "12",
journal = "Journal of Tissue Engineering",
issn = "2041-7314",
publisher = "SAGE-Hindawi Access to Research",
}