TY - JOUR
T1 - Practical synthesis of (E)-α,β-unsaturated esters from aldehydes
AU - List, Benjamin
AU - Doehring, Arno
AU - Hechavarria Fonseca, Maria T.
AU - Wobser, Kathrin
AU - Van Thienen, Hendrik
AU - Torres, Ramon Rios
AU - Galilea, Pedro Llamas
PY - 2005/10
Y1 - 2005/10
N2 - Based on a modification of the Doebner-Knoevenagel reaction, a practical and highly efficient synthesis of β,β-unsaturated esters with excellent regio- and stereoselectivity was developed. The reactions are catalyzed by 4-dimethylaminopyridine in DMF at room temperature or below. Both aliphatic and aromatic aldehydes can readily be used in the process.
AB - Based on a modification of the Doebner-Knoevenagel reaction, a practical and highly efficient synthesis of β,β-unsaturated esters with excellent regio- and stereoselectivity was developed. The reactions are catalyzed by 4-dimethylaminopyridine in DMF at room temperature or below. Both aliphatic and aromatic aldehydes can readily be used in the process.
KW - α,β-unsaturated esters
KW - (E)-stereoselectivity
KW - Atom economy
KW - Doebner-Knoevenagel reaction
KW - Malonic acid half esters
UR - https://www.scopus.com/pages/publications/27544497003
U2 - 10.1002/adsc.200505196
DO - 10.1002/adsc.200505196
M3 - Article
AN - SCOPUS:27544497003
SN - 1615-4150
VL - 347
SP - 1558
EP - 1560
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 11-13
ER -