Povezanost varijacija LPIN1 gena s markerima metaboličkog sindroma u populaciji Bosne i Hercegovine

Translated title of the contribution: Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina

Tamer Bego, Tanja Dujić, Barbara Mlinar, Sabina Semiz, Maja Malenica, Besim Prnjavorac, Barbara Ostanek, Janja Marc, Anida Čaušević-Ramoševac, Adlija Čaušević

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aim To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina. Methods This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real time PCR method. Results In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients. Conclusion Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.

Translated title of the contributionAssociation of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina
Original languageUndefined/Unknown
Pages (from-to)113-121
Number of pages9
JournalMedicinski Glasnik
Volume12
Issue number2
StatePublished - Aug 2015

Keywords

  • Gene variations
  • LPIN1 gene
  • Markers
  • Metabolic syndrome

Fingerprint

Dive into the research topics of 'Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina'. Together they form a unique fingerprint.

Cite this