TY - JOUR
T1 - Polymer nanoparticles containing 2,4,6-triiodophenol
T2 - A potential contrast medium for medical imaging
AU - El-Batta, Amer
AU - Al-Muallem, Hasan A.
AU - Shaikh, M. Nasiruzzaman
AU - Maalej, Nabil
PY - 2014
Y1 - 2014
N2 - Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate 2,4,6-triiodophenol in a polymer matrix were designed. Spherical NPs made of PLA, PLGA, PLA-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water singleemulsion technique, the effect of several experimental parameters such as sonication power, ratio of 2,4,6-triiodophenol/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped 2,4,6-triiodophenol was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.
AB - Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate 2,4,6-triiodophenol in a polymer matrix were designed. Spherical NPs made of PLA, PLGA, PLA-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water singleemulsion technique, the effect of several experimental parameters such as sonication power, ratio of 2,4,6-triiodophenol/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped 2,4,6-triiodophenol was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.
KW - 2 4 6-triiodophenol
KW - Biodegradable copolymer
KW - Iodine encapsulation
KW - Polymer nanoparticles
KW - X-ray contrast
KW - X-ray imaging
UR - http://www.scopus.com/inward/record.url?scp=84903165629&partnerID=8YFLogxK
M3 - Article
C2 - 25125126
AN - SCOPUS:84903165629
SN - 1318-0207
VL - 61
SP - 414
EP - 419
JO - Acta Chimica Slovenica
JF - Acta Chimica Slovenica
IS - 2
ER -