Polymer nanoparticles containing 2,4,6-triiodophenol: A potential contrast medium for medical imaging

Amer El-Batta, Hasan A. Al-Muallem, M. Nasiruzzaman Shaikh, Nabil Maalej

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate 2,4,6-triiodophenol in a polymer matrix were designed. Spherical NPs made of PLA, PLGA, PLA-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water singleemulsion technique, the effect of several experimental parameters such as sonication power, ratio of 2,4,6-triiodophenol/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped 2,4,6-triiodophenol was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.

Original languageBritish English
Pages (from-to)414-419
Number of pages6
JournalActa Chimica Slovenica
Volume61
Issue number2
StatePublished - 2014

Keywords

  • 2 4 6-triiodophenol
  • Biodegradable copolymer
  • Iodine encapsulation
  • Polymer nanoparticles
  • X-ray contrast
  • X-ray imaging

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