PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Junaid Kashir; Michail Nomikos; Karl Swann; F. Anthony Lai

doi:10.1093/molehr/gav009

PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Junaid Kashir, Michail Nomikos, Karl Swann, F. Anthony Lai

Biological Sciences

Cardiff University School of Medicine

Research output: Contribution to journal › Comment/debate

30 Scopus citations

Abstract

In mammals, egg activation is initiated by multiple cytosolic Ca²⁺ transients (Ca²⁺ oscillations) that are triggered following delivery of a putative sperm factor fromthe fertilizing sperm. The identity of this 'sperm factor' thus holdsmuchsignificance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheathWWdomain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.

Original language	British English
Pages (from-to)	383-388
Number of pages	6
Journal	Molecular Human Reproduction
Volume	21
Issue number	5
DOIs	https://doi.org/10.1093/molehr/gav009
State	Published - 21 Jul 2014

Keywords

Egg activation
Fertilization
PAWP
PLC-zeta
Sperm factor

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10.1093/molehr/gav009

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title = "PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis",

abstract = "In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor fromthe fertilizing sperm. The identity of this 'sperm factor' thus holdsmuchsignificance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheathWWdomain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.",

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T2 - Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

AU - Kashir, Junaid

AU - Nomikos, Michail

AU - Swann, Karl

AU - Lai, F. Anthony

N1 - Publisher Copyright: © The Author 2015.

PY - 2014/7/21

Y1 - 2014/7/21

N2 - In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor fromthe fertilizing sperm. The identity of this 'sperm factor' thus holdsmuchsignificance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheathWWdomain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.

AB - In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor fromthe fertilizing sperm. The identity of this 'sperm factor' thus holdsmuchsignificance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheathWWdomain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.

KW - Egg activation

KW - Fertilization

KW - PAWP

KW - PLC-zeta

KW - Sperm factor

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PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

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Keywords

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