PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Junaid Kashir, Michail Nomikos, Karl Swann, F. Anthony Lai

Research output: Contribution to journalComment/debate

26 Scopus citations

Abstract

In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor fromthe fertilizing sperm. The identity of this 'sperm factor' thus holdsmuchsignificance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheathWWdomain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.

Original languageBritish English
Pages (from-to)383-388
Number of pages6
JournalMolecular Human Reproduction
Volume21
Issue number5
DOIs
StatePublished - 21 Jul 2014

Keywords

  • Egg activation
  • Fertilization
  • PAWP
  • PLC-zeta
  • Sperm factor

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