Abstract
Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.
| Original language | British English |
|---|---|
| Pages (from-to) | 24993-24997 |
| Number of pages | 5 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 7 |
| Issue number | 45 |
| DOIs | |
| State | Published - 25 Sep 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- bridged silsesquioxane
- charge reversal
- DNA delivery
- hollow nanoparticles
- organosilica
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