Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Yevhen Fatieiev, Jonas G. Croissant, Shahad Alsaiari, Basem A. Moosa, Dalaver H. Anjum, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

Original languageBritish English
Pages (from-to)24993-24997
Number of pages5
JournalACS Applied Materials and Interfaces
Volume7
Issue number45
DOIs
StatePublished - 25 Sep 2015

Keywords

  • bridged silsesquioxane
  • charge reversal
  • DNA delivery
  • hollow nanoparticles
  • organosilica

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