Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Yevhen Fatieiev; Jonas G. Croissant; Shahad Alsaiari; Basem A. Moosa; Dalaver H. Anjum; Niveen M. Khashab

doi:10.1021/acsami.5b07365

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Yevhen Fatieiev, Jonas G. Croissant, Shahad Alsaiari, Basem A. Moosa, Dalaver H. Anjum, Niveen M. Khashab

Physics

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

Original language	British English
Pages (from-to)	24993-24997
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	7
Issue number	45
DOIs	https://doi.org/10.1021/acsami.5b07365
State	Published - 25 Sep 2015

Keywords

bridged silsesquioxane
charge reversal
DNA delivery
hollow nanoparticles
organosilica

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.5b07365

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title = "Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery",

abstract = "Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.",

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author = "Yevhen Fatieiev and Croissant, {Jonas G.} and Shahad Alsaiari and Moosa, {Basem A.} and Anjum, {Dalaver H.} and Khashab, {Niveen M.}",

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AU - Fatieiev, Yevhen

AU - Croissant, Jonas G.

AU - Alsaiari, Shahad

AU - Moosa, Basem A.

AU - Anjum, Dalaver H.

AU - Khashab, Niveen M.

PY - 2015/9/25

Y1 - 2015/9/25

N2 - Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

AB - Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

KW - bridged silsesquioxane

KW - charge reversal

KW - DNA delivery

KW - hollow nanoparticles

KW - organosilica

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Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Abstract

Keywords

UN SDGs

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