Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening

Trapti Aggarwal, Rajeev R. Jha, Rakesh K. Tiwari, Sonu Kumar, Siva K.Reddy Kotla, Sushil Kumar, Akhilesh K. Verma

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    39 Scopus citations

    Abstract

    A regioselective tandem synthesis of highly functionalized pyrrolo[1,2-a]quinolines has been developed through a novel strategy by palladium-catalyzed [3 + 2] annulation of iodo-pyranoquinolines and internal alkynes with subsequent ring opening. Pyranoquinoline with n-alkyl substitution at the 3-position leads to the formation of pyrrolo-acridones via [3 + 2] annulations/ring opening and successive intramolecular cross-aldol condensation.

    Original languageBritish English
    Pages (from-to)5184-5187
    Number of pages4
    JournalOrganic Letters
    Volume14
    Issue number20
    DOIs
    StatePublished - 19 Oct 2012

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