Abstract
A regioselective tandem synthesis of highly functionalized pyrrolo[1,2-a]quinolines has been developed through a novel strategy by palladium-catalyzed [3 + 2] annulation of iodo-pyranoquinolines and internal alkynes with subsequent ring opening. Pyranoquinoline with n-alkyl substitution at the 3-position leads to the formation of pyrrolo-acridones via [3 + 2] annulations/ring opening and successive intramolecular cross-aldol condensation.
Original language | British English |
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Pages (from-to) | 5184-5187 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 20 |
DOIs | |
State | Published - 19 Oct 2012 |