TY - JOUR
T1 - Oxygen-Releasing Biomaterials
T2 - Current Challenges and Future Applications
AU - Willemen, Niels G.A.
AU - Hassan, Shabir
AU - Gurian, Melvin
AU - Li, Jinghang
AU - Allijn, Iris E.
AU - Shin, Su Ryon
AU - Leijten, Jeroen
N1 - Funding Information:
Je.L. acknowledges financial support from an Innovative Research Incentives Scheme Vidi award (#17522) from The Netherlands Organization for Scientific Research (NWO), European Research Council (ERC, Starting Grant, #759425), and Health-Holland (#LSHM19074). This paper was funded by the National Institutes of Health (R01AR074234) and AHA Innovative Project Award (19IPLOI34660079). N.W. S.H. M.G. Ji.L. and I.A. wrote the manuscript. N.W. and Eduardo Enciso-Martinez produced the figures. N.W. S.H. S.S. and Je.L. designed section structures and edited the review. All authors read and agreed to published version of the manuscript. The authors declare no conflict of interest.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/11
Y1 - 2021/11
N2 - Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.
AB - Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.
KW - biomaterials
KW - hypoxia
KW - metabolism
KW - oxygen generation
KW - sustained release
UR - http://www.scopus.com/inward/record.url?scp=85101352322&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2021.01.007
DO - 10.1016/j.tibtech.2021.01.007
M3 - Review article
C2 - 33602609
AN - SCOPUS:85101352322
SN - 0167-7799
VL - 39
SP - 1144
EP - 1159
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -