Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus

Hayder A. Al-Aubaidy, Herbert F. Jelinek

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The mechanism by which postprandial glucose load and sudden cardiac death are linked is not fully understood. This study compares the postprandial response of 8-hydroxy-deoxy-guanosine (8-OHdG)and erythrocyte glutathione (GSH) in control and type 2 diabetes groups. 8-OHdG was significantly elevated in type 2 diabetic patients (824.1±331.2 and 1087±273.1 pg/ml at the first and second hours respectively, p<0.05, versus 600.4±214.4 pg/ml at baseline) following a glucose load. This was associated with a significant reduction in the level of erythrocyte GSH after the first hour (59.1±9 mg/100ml; p<0.001) compared with the basal level (72.1±9 mg/100ml), followed by a significant elevation in the second hour (71.5±11.1 mg/100ml; p<0.001) compared with the first hour, bringing the GSH level only back to base level. The increase in 8-OHdG in people with type 2 diabetes during the postprandial period further supports previous evidence of a defective antioxidant response and greater risk of heart attack due to blood vessel endothelial cell damage and smooth muscle proliferation.

Original languageBritish English
Pages (from-to)87-91
Number of pages5
JournalBritish Journal of Diabetes and Vascular Disease
Volume11
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • 8-hydroxy-deoxy- guanosine
  • erythrocyte reduced glutathione
  • oral glucose tolerance test
  • type 2 diabetes mellitus

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