Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives

Wajid Mohammad Sheikh; Showkeen Muzamil Bashir; Bashie; Jasmeena Jan; Insha Mehraj; Zeeshan Hyderi; Bilal Ahmad Rather; Shazia Javeed; Ubaid Sayed Shah; Seerat Ul Fatima; Indrani Jadhav; Junaid Kashir

doi:10.1016/B978-0-443-23908-3.00020-4

Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives

Wajid Mohammad Sheikh
, Showkeen Muzamil Bashir
, Bashie
, Jasmeena Jan
, Insha Mehraj
, Zeeshan Hyderi
, Bilal Ahmad Rather
, Shazia Javeed
, Ubaid Sayed Shah
, Seerat Ul Fatima
, Indrani Jadhav
, Junaid Kashir

Sher-e-Kashmir University of Agricultural Sciences and Technology
University of Kashmir
Baba Ghulam Shah Badshah University
Alagappa University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Mainstream treatment methods currently include chemotherapy, radiotherapy, and surgical debulking for ovarian cancer (OC). To enhance survival rates for patients diagnosed in advanced stages, it is vital to tackle issues like drug resistance, angiogenesis, relapse, and metastasis. Recent developments in treatment approaches, possible biomarkers, and technological enhancements discussed in this piece can offer promising insights for better management of OC. The review emphasizes the urgency to comprehend the intricate biology of the disease and spot potential biomarkers for early diagnosis and predicting treatment responses. It discusses current therapeutic strategies and research related to potential biomarkers. By advancing technology and exploring novel biomarkers, there is a focus on improving diagnosis accuracy, treatment outcomes, and ultimately enhancing patients’ survival and well-being.

Original language	British English
Title of host publication	Proteomics
Subtitle of host publication	A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2
Publisher	Elsevier
Pages	211-226
Number of pages	16
Volume	2
ISBN (Electronic)	9780443239083
ISBN (Print)	9780443239076
DOIs	https://doi.org/10.1016/B978-0-443-23908-3.00020-4
State	Published - 1 Jan 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

angiogenesis
novel biomarkers
Ovarian cancer
therapeutic procedure
therapeutic strategies

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Sheikh, W. M., Bashir, S. M., Bashie, Jan, J., Mehraj, I., Hyderi, Z., Ahmad Rather, B., Javeed, S., Sayed Shah, U., Ul Fatima, S., Jadhav, I., & Kashir, J. (2026). Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives. In Proteomics: A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2 (Vol. 2, pp. 211-226). Elsevier. https://doi.org/10.1016/B978-0-443-23908-3.00020-4

Sheikh, Wajid Mohammad ; Bashir, Showkeen Muzamil ; Bashie et al. / Ovarian cancer : vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives. Proteomics: A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2. Vol. 2 Elsevier, 2026. pp. 211-226

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abstract = "Mainstream treatment methods currently include chemotherapy, radiotherapy, and surgical debulking for ovarian cancer (OC). To enhance survival rates for patients diagnosed in advanced stages, it is vital to tackle issues like drug resistance, angiogenesis, relapse, and metastasis. Recent developments in treatment approaches, possible biomarkers, and technological enhancements discussed in this piece can offer promising insights for better management of OC. The review emphasizes the urgency to comprehend the intricate biology of the disease and spot potential biomarkers for early diagnosis and predicting treatment responses. It discusses current therapeutic strategies and research related to potential biomarkers. By advancing technology and exploring novel biomarkers, there is a focus on improving diagnosis accuracy, treatment outcomes, and ultimately enhancing patients{\textquoteright} survival and well-being.",

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Sheikh, WM, Bashir, SM, Bashie, Jan, J, Mehraj, I, Hyderi, Z, Ahmad Rather, B, Javeed, S, Sayed Shah, U, Ul Fatima, S, Jadhav, I & Kashir, J 2026, Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives. in Proteomics: A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2. vol. 2, Elsevier, pp. 211-226. https://doi.org/10.1016/B978-0-443-23908-3.00020-4

Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives. / Sheikh, Wajid Mohammad; Bashir, Showkeen Muzamil; Bashie et al.
Proteomics: A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2. Vol. 2 Elsevier, 2026. p. 211-226.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Sheikh, Wajid Mohammad

AU - Bashir, Showkeen Muzamil

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AU - Jan, Jasmeena

AU - Mehraj, Insha

AU - Hyderi, Zeeshan

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AU - Javeed, Shazia

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AB - Mainstream treatment methods currently include chemotherapy, radiotherapy, and surgical debulking for ovarian cancer (OC). To enhance survival rates for patients diagnosed in advanced stages, it is vital to tackle issues like drug resistance, angiogenesis, relapse, and metastasis. Recent developments in treatment approaches, possible biomarkers, and technological enhancements discussed in this piece can offer promising insights for better management of OC. The review emphasizes the urgency to comprehend the intricate biology of the disease and spot potential biomarkers for early diagnosis and predicting treatment responses. It discusses current therapeutic strategies and research related to potential biomarkers. By advancing technology and exploring novel biomarkers, there is a focus on improving diagnosis accuracy, treatment outcomes, and ultimately enhancing patients’ survival and well-being.

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Sheikh WM, Bashir SM, Bashie, Jan J, Mehraj I, Hyderi Z et al. Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives. In Proteomics: A Promising Approach for Cancer Research: Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2. Vol. 2. Elsevier. 2026. p. 211-226 doi: 10.1016/B978-0-443-23908-3.00020-4

Ovarian cancer: vascular endothelial growth factor signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives

Abstract

UN SDGs

Keywords

Access to Document

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