Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates

Bing Wang; Xavier Companyó; Jing Li; Albert Moyano; Ramon Rios

doi:10.1016/j.tetlet.2012.05.121

Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates

Bing Wang
, Xavier Companyó
, Jing Li
, Albert Moyano
, Ramon Rios

Chemistry

Nankai University
Universitat de Barcelona

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The enantioselective fluoromalonate addition to Morita-Baylis-Hillman carbonates is presented. The reaction is simply catalyzed by β-isocupreidine affording the final fluorinated products in good yields and enantioselectivities.

Original language	British English
Pages (from-to)	4124-4129
Number of pages	6
Journal	Tetrahedron Letters
Volume	53
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2012.05.121
State	Published - 8 Aug 2012

Keywords

Enantioselective
Fluorine
Lewis base
MBH carbonates
Organocatalysis

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title = "Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates",

abstract = "The enantioselective fluoromalonate addition to Morita-Baylis-Hillman carbonates is presented. The reaction is simply catalyzed by β-isocupreidine affording the final fluorinated products in good yields and enantioselectivities.",

keywords = "Enantioselective, Fluorine, Lewis base, MBH carbonates, Organocatalysis",

author = "Bing Wang and Xavier Company{\'o} and Jing Li and Albert Moyano and Ramon Rios",

note = "Funding Information: We thank the Spanish Ministry of Science and Innovation (MICINN) for financial support (Project AYA2009-13920-C02-02). X.C. thanks MICINN for a predoctoral fellowship. B.W. is grateful to China Scholarship Council for a fellowship. ",

year = "2012",

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doi = "10.1016/j.tetlet.2012.05.121",

language = "British English",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates

AU - Wang, Bing

AU - Companyó, Xavier

AU - Li, Jing

AU - Moyano, Albert

AU - Rios, Ramon

N1 - Funding Information: We thank the Spanish Ministry of Science and Innovation (MICINN) for financial support (Project AYA2009-13920-C02-02). X.C. thanks MICINN for a predoctoral fellowship. B.W. is grateful to China Scholarship Council for a fellowship.

PY - 2012/8/8

Y1 - 2012/8/8

N2 - The enantioselective fluoromalonate addition to Morita-Baylis-Hillman carbonates is presented. The reaction is simply catalyzed by β-isocupreidine affording the final fluorinated products in good yields and enantioselectivities.

AB - The enantioselective fluoromalonate addition to Morita-Baylis-Hillman carbonates is presented. The reaction is simply catalyzed by β-isocupreidine affording the final fluorinated products in good yields and enantioselectivities.

KW - Enantioselective

KW - Fluorine

KW - Lewis base

KW - MBH carbonates

KW - Organocatalysis

UR - https://www.scopus.com/pages/publications/84863621863

U2 - 10.1016/j.tetlet.2012.05.121

DO - 10.1016/j.tetlet.2012.05.121

M3 - Article

AN - SCOPUS:84863621863

SN - 0040-4039

VL - 53

SP - 4124

EP - 4129

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates

Abstract

Keywords

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