Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course

Andrea Mazzanti; Teresa Calbet; Merce Font-Bardia; Albert Moyano; Ramon Rios

doi:10.1039/c2ob06553c

Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course

Andrea Mazzanti
, Teresa Calbet
, Merce Font-Bardia
, Albert Moyano
, Ramon Rios

Chemistry

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The enantioselective synthesis of pyrazol-3-ones has not been extensively studied in organic synthesis. Here in we report the first asymmetric addition of pyrazolones to maleimides catalyzed by bifunctional thiourea catalysts.

Original language	British English
Pages (from-to)	1645-1652
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	8
DOIs	https://doi.org/10.1039/c2ob06553c
State	Published - 28 Feb 2012

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title = "Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course",

abstract = "The enantioselective synthesis of pyrazol-3-ones has not been extensively studied in organic synthesis. Here in we report the first asymmetric addition of pyrazolones to maleimides catalyzed by bifunctional thiourea catalysts.",

author = "Andrea Mazzanti and Teresa Calbet and Merce Font-Bardia and Albert Moyano and Ramon Rios",

note = "Funding Information: This research was funded by the National Natural Science Foundation of China (Grant No. 51674004) and Education Department of Anhui Province of China (Grant Nos. KJ2016A104 and KJ2017A805).",

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AU - Mazzanti, Andrea

AU - Calbet, Teresa

AU - Font-Bardia, Merce

AU - Moyano, Albert

AU - Rios, Ramon

N1 - Funding Information: This research was funded by the National Natural Science Foundation of China (Grant No. 51674004) and Education Department of Anhui Province of China (Grant Nos. KJ2016A104 and KJ2017A805).

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N2 - The enantioselective synthesis of pyrazol-3-ones has not been extensively studied in organic synthesis. Here in we report the first asymmetric addition of pyrazolones to maleimides catalyzed by bifunctional thiourea catalysts.

AB - The enantioselective synthesis of pyrazol-3-ones has not been extensively studied in organic synthesis. Here in we report the first asymmetric addition of pyrazolones to maleimides catalyzed by bifunctional thiourea catalysts.

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JO - Organic and Biomolecular Chemistry

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Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course

Abstract

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