Abstract
(Chemical Equation Presented) Simple chiral amines catalyze a highly chemo- and enantioselective aziridination of α,β-unsaturated aldehydes to provide 2-formylaziridines in good yields and with up to 99% ee. The synthetic utility of this organocatalytic method was exemplified in a two-step asymmetric synthesis of β-amino acid esters with readily removable protecting groups (see scheme; R1 = tert-butoxycarbonyl, benzyloxycarbonyl).
| Original language | British English |
|---|---|
| Pages (from-to) | 778-781 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 46 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2007 |
Keywords
- β-amino acids
- Asymmetric catalysis
- Aziridines
- Domino reactions
- Organocatalysis