Organocatalytic enantioselective aminosulfenylation of α,β- unsaturated aldehydes

(Chemical Equation Presented) Domino theory: A simple, highly enantioselective organocatalytic aminosulfenylation of α,β- unsaturated aldehydes affords orthogonally protected β-amino-α- mercaptoaldehydes in high yields and 93 to >99% ee (see scheme, Bn=benzyl). Notably, the catalytic transformation shows that it is possible to efficiently employ all components of an electrophile, which includes a nucleofuge, in organocatalytic domino reactions of enals.