Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

Ismail Ibrahem; Ramon Rios; Jan Vesely; Armando Córdova

doi:10.1016/j.tetlet.2007.07.031

Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

Ismail Ibrahem, Ramon Rios, Jan Vesely, Armando Córdova

Chemistry

Arrhenius Laboratory

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and α,β-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90-98% ee.

Original language	British English
Pages (from-to)	6252-6257
Number of pages	6
Journal	Tetrahedron Letters
Volume	48
Issue number	36
DOIs	https://doi.org/10.1016/j.tetlet.2007.07.031
State	Published - 3 Sep 2007

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10.1016/j.tetlet.2007.07.031

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title = "Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives",

abstract = "The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and α,β-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90-98% ee.",

author = "Ismail Ibrahem and Ramon Rios and Jan Vesely and Armando C{\'o}rdova",

note = "Funding Information: We gratefully acknowledge the Swedish National Research Council, Wenner-Gren, and Carl-Trygger Foundations for financial support. ",

year = "2007",

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doi = "10.1016/j.tetlet.2007.07.031",

language = "British English",

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pages = "6252--6257",

journal = "Tetrahedron Letters",

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T1 - Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

AU - Ibrahem, Ismail

AU - Rios, Ramon

AU - Vesely, Jan

AU - Córdova, Armando

N1 - Funding Information: We gratefully acknowledge the Swedish National Research Council, Wenner-Gren, and Carl-Trygger Foundations for financial support.

PY - 2007/9/3

Y1 - 2007/9/3

N2 - The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and α,β-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90-98% ee.

AB - The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and α,β-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90-98% ee.

UR - http://www.scopus.com/inward/record.url?scp=34547682312&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2007.07.031

DO - 10.1016/j.tetlet.2007.07.031

M3 - Article

AN - SCOPUS:34547682312

SN - 0040-4039

VL - 48

SP - 6252

EP - 6257

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

Abstract

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