Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis: a highly enantioselective route to 3-substituted proline derivatives

Ramon Rios, Ismail Ibrahem, Jan Vesely, Henrik Sundén, Armando Córdova

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The highly enantioselective organocatalytic tandem reaction between 2-acylaminomalonates and α,β-unsaturated aldehydes is presented. The reaction is a direct entry to 5-hydroxypyrrolidines and 3-substituted proline derivatives, which are furnished in high yields and 90-99% ee.

Original languageBritish English
Pages (from-to)8695-8699
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number49
DOIs
StatePublished - 3 Dec 2007

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