Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids

Ismail Ibrahem; Ramon Rios; Jan Vesely; Gui Ling Zhao; Armando Córdova

doi:10.1039/b613410f

Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids

Ismail Ibrahem, Ramon Rios, Jan Vesely, Gui Ling Zhao, Armando Córdova

Chemistry

Arrhenius Laboratory

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee.

Original language	British English
Pages (from-to)	849-851
Number of pages	3
Journal	Chemical Communications
Issue number	8
DOIs	https://doi.org/10.1039/b613410f
State	Published - 2007

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title = "Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids",

abstract = "The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee.",

author = "Ismail Ibrahem and Ramon Rios and Jan Vesely and Zhao, {Gui Ling} and Armando C{\'o}rdova",

year = "2007",

doi = "10.1039/b613410f",

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journal = "Chemical Communications",

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T1 - Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis

T2 - A highly enantioselective route to β-amino acids

AU - Ibrahem, Ismail

AU - Rios, Ramon

AU - Vesely, Jan

AU - Zhao, Gui Ling

AU - Córdova, Armando

PY - 2007

Y1 - 2007

N2 - The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee.

AB - The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee.

UR - http://www.scopus.com/inward/record.url?scp=33847051178&partnerID=8YFLogxK

U2 - 10.1039/b613410f

DO - 10.1039/b613410f

M3 - Article

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AN - SCOPUS:33847051178

SN - 1359-7345

SP - 849

EP - 851

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids

Abstract

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