Organic Transistor Arrays Integrated with Finger-Powered Microfluidics for Multianalyte Saliva Testing

Anna Maria Pappa, Vincenzo F. Curto, Marcel Braendlein, Xenofon Strakosas, Mary J. Donahue, Michel Fiocchi, George G. Malliaras, Roisin M. Owens

Research output: Contribution to journalArticlepeer-review

155 Scopus citations

Abstract

A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless “finger-powered” microfluidic, for quantitative screening of glucose, lactate, and cholesterol levels. A biofunctionalization method is designed, which provides selectivity towards specific metabolites as well as minimization of any background interference. In addition, a simple method is developed to facilitate multi-analyte sensing and avoid electrical crosstalk between the different transistors by electrically isolating the individual devices. The resulting biosensing platform, verified using human samples, offers the possibility to be used in easy-to-obtain biofluids with low abundance metabolites, such as saliva. Based on our proposed method, other types of enzymatic biosensors can be integrated into the array to achieve multiplexed, noninvasive, personalized point-of-care diagnostics.

Original languageBritish English
Pages (from-to)2295-2302
Number of pages8
JournalAdvanced Healthcare Materials
Volume5
Issue number17
DOIs
StatePublished - 7 Sep 2016

Keywords

  • microfluidics
  • multianalyte
  • organic electrochemical transistors
  • point-of-care diagnostics
  • saliva

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