Optimising cancer chemotherapy using an estimation of distribution algorithm and genetic algorithms

Andrei Petrovski, Siddhartha Shakya, John McCall

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

39 Scopus citations

Abstract

This paper presents a methodology for using heuristic search methods to optimise cancer chemotherapy. Specifically, two evolutionary algorithms - Population Based Incremental Learning (PBIL), which is an Estimation of Distribution Algorithm (EDA), and Genetic Algorithms (GAs) have been applied to the problem of finding effective chemotherapeutic treatments. To our knowledge. EDAs have been applied to fewer real world problems compared to GAs, and the aim of the present paper is to expand the application domain of this technique. We compare and analyse the performance of both algorithms and draw a conclusion as to which approach to cancer chemotherapy optimisation is more efficient and helpful in the decision-making activity led by the oncologists.

Original languageBritish English
Title of host publicationGECCO 2006 - Genetic and Evolutionary Computation Conference
PublisherAssociation for Computing Machinery (ACM)
Pages413-418
Number of pages6
ISBN (Print)1595931864, 9781595931863
DOIs
StatePublished - 2006
Event8th Annual Genetic and Evolutionary Computation Conference 2006 - Seattle, WA, United States
Duration: 8 Jul 200612 Jul 2006

Publication series

NameGECCO 2006 - Genetic and Evolutionary Computation Conference
Volume1

Conference

Conference8th Annual Genetic and Evolutionary Computation Conference 2006
Country/TerritoryUnited States
CitySeattle, WA
Period8/07/0612/07/06

Keywords

  • Estimation of Distribution Algorithms
  • Evolutionary Computation
  • Probabilistic Modelling

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