Optimal vaccine roll-out strategies including social distancing for pandemics

Konstantinos Spiliotis, Constantinos Chr Koutsoumaris, Andreas I. Reppas, Lito A. Papaxenopoulou, Jens Starke, Haralampos Hatzikirou

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Non-pharmacological interventions (NPIs), principally social distancing, in combination with effective vaccines, aspire to develop a protective immunity shield against pandemics and particularly against the COVID-19 pandemic. In this study, an agent-based network model with small-world topology is employed to find optimal policies against pandemics, including social distancing and vaccination strategies. The agents’ states are characterized by a variation of the SEIR model (susceptible, exposed, infected, recovered). To explore optimal policies, an equation-free method is proposed to solve the inverse problem of calibrating an agent's infection rate with respect to the vaccination efficacy. The results show that prioritizing the first vaccine dose in combination with mild social restrictions, is sufficient to control the pandemic, with respect to the number of deaths. Moreover, for the same mild number of social contacts, we find an optimal vaccination ratio of 0.85 between older people of ages >65 compared to younger ones.

Original languageBritish English
Article number104575
JournaliScience
Volume25
Issue number7
DOIs
StatePublished - 15 Jul 2022

Keywords

  • Health sciences
  • Public health
  • Virology

Fingerprint

Dive into the research topics of 'Optimal vaccine roll-out strategies including social distancing for pandemics'. Together they form a unique fingerprint.

Cite this