Abstract
An extremely efficient, highly diastereoselective, metal-free synthesis of 2,3,4,5-tetrasubstituted pyrrolidines is described. The three-component reaction between aldehydes, aminomalonates, and nitroalkenes proceeds with high diastereoselectivities and high yields.
| Original language | British English |
|---|---|
| Pages (from-to) | 1840-1844 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 12 |
| DOIs | |
| State | Published - 16 Jul 2008 |
Keywords
- Cycloaddition
- Metal-free
- Pyrrolidines
- Stereoselectivity
- Three component