One-pot organocatalytic domino Michael/α-alkylation reactions: highly enantioselective synthesis of functionalized cyclopentanones and cyclopentanols

Ramon Rios, Jan Vesely, Henrik Sundén, Ismail Ibrahem, Gui Ling Zhao, Armando Córdova

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

A simple, highly enantioselective catalytic route to cyclopentanones is presented. The chiral amine catalyzed domino Michael/α-alkylation reaction gives access to functionalized cyclopentanones in good to high yields with 93 → 99% ee. The products were also reduced with high diastereoselectivity to the corresponding cyclopentanols.

Original languageBritish English
Pages (from-to)5835-5839
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number33
DOIs
StatePublished - 13 Aug 2007

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