One-pot highly enantioselective catalytic Mannich-type reactions between aldehydes and stable α-amido sulfones: asymmetric synthesis of β-amino aldehydes and β-amino acids

Luca Deiana, Gui Ling Zhao, Pawel Dziedzic, Ramon Rios, Jan Vesely, Jesper Ekström, Armando Córdova

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Abstract

A highly enantioselective catalytic route to carbamate- and benzoate-protected β-amino aldehydes and β-amino acids is presented. The amino acid-catalyzed one-pot asymmetric reaction between unmodified aldehydes and α-amido sulfones gives the corresponding β-amino compounds with up to 95:5 dr and 97->99% ee.

Original languageBritish English
Pages (from-to)234-237
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number2
DOIs
StatePublished - 13 Jan 2010

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