One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives

Jan Vesely, Ramon Rios, Ismail Ibrahem, Gui Lins Zhao, Lars Eriksson, Armando Córdova

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiralamine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (> 25:1 d.r. and 98- >99 ee).

Original languageBritish English
Pages (from-to)2693-2698
Number of pages6
JournalChemistry - A European Journal
Volume14
Issue number9
DOIs
StatePublished - 17 Mar 2008

Keywords

  • Asymmetric catalysis
  • Cascade reaction
  • Chiral amines
  • Cycloaddition
  • Cycloheptane derivatives

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