On the impact of chemo-mechanically induced phenotypic transitions in gliomas

Pietro Mascheroni, Juan Carlos López Alfonso, Maria Kalli, Triantafyllos Stylianopoulos, Michael Meyer-Hermann, Haralampos Hatzikirou

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo–mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes.

Original languageBritish English
Article number716
JournalCancers
Volume11
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Glioma
  • Phenotypic transitions
  • Solid stress
  • Stress-alleviation therapy

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