Non-invasive evaluation of opening and closing timings of the cardiac valves in the fetal cardiac cycle

A. H. Khandoker, Y. Kimura, T. Ito, N. Sato, K. Okamura, M. Palaniswami

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


In this study, we propose a non-invasive system to recognize the timings of fetal cardiac events on the basis of analysis of fetal ECG and Doppler ultrasound signal together. Fetal ECG was extracted from transabdominal ECG (10 normal subjects, 38-41 weeks of gestation) using blind source separation with the reference signal. Multiresolution wavelet analysis enabled the frequency contents of the Doppler signals to be linked to the opening(o) and closing(c) of the heart's valves (Aortic (A) and mitral(M)). M-mode, B-mode and pulsed Doppler ultrasound were used to examine and verify the timings of opening and closure of aortic as well as mitral valves. The time intervals from Q-wave of QRS complex of fetal ECG to opening and closing of aortic valve, i.e. Q-Ao and Q-Ac were found to be 75.0±11.9 (msec) and 221.6±29.0 (msec) respectively. As for the mitral valve, Q-Mc and Q-Mo were found to be 45.0±18.9 (msec) and 301.6±20.7 (msec) respectively.

Original languageBritish English
Title of host publicationComputers in Cardiology 2008, CAR
Number of pages4
StatePublished - 2008
EventComputers in Cardiology 2008, CAR - Bologna, Italy
Duration: 14 Sep 200817 Sep 2008

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574


ConferenceComputers in Cardiology 2008, CAR


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