N,N′-Dialkyl-4-Aryl-3,4-Dihydropyrimidinones and Thiones: Ceric Ammonium Nitrate Catalyzed Synthesis and Molecular Structure Determination by X-ray Crystallography

This work presents a microwave assisted solvent-free synthesis of N,N′-dialkyl-4-aryl-3,4-dihydropyrimidinones/thiones in the presence of Ceric Ammonium Nitrate (CAN) via direct condensation of aromatic aldehydes, β-keto ester, and N,N′-dialkylurea/thiourea. The highlights of the methodology adopted are (i) facile condensation of the reactants into product without any side-products, and (ii) short reaction time with high yield and good purity. All the compounds synthesized were characterized and established by spectroscopic techniques such as FTIR, ¹H NMR, ¹³C NMR, and Mass. The structure of the compound is further corroborated by single crystal X-ray diffraction analysis.