Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells

Tina Skorjanc; Dinesh Shetty; Sushil Kumar; Damjan Makuc; Gregor Mali; Janez Volavšek; Martina Bergant Marušič; Matjaz Valant

doi:10.1039/d3cc01110k

Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells

Tina Skorjanc, Dinesh Shetty, Sushil Kumar, Damjan Makuc, Gregor Mali, Janez Volavšek, Martina Bergant Marušič, Matjaz Valant

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a β-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.

Original language	British English
Pages (from-to)	5753-5756
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	38
DOIs	https://doi.org/10.1039/d3cc01110k
State	Published - 24 Apr 2023

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10.1039/d3cc01110k

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title = "Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells",

abstract = "Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a β-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.",

author = "Tina Skorjanc and Dinesh Shetty and Sushil Kumar and Damjan Makuc and Gregor Mali and Janez Volav{\v s}ek and {Bergant Maru{\v s}i{\v c}}, Martina and Matjaz Valant",

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AU - Skorjanc, Tina

AU - Shetty, Dinesh

AU - Kumar, Sushil

AU - Makuc, Damjan

AU - Mali, Gregor

AU - Volavšek, Janez

AU - Bergant Marušič, Martina

AU - Valant, Matjaz

PY - 2023/4/24

Y1 - 2023/4/24

N2 - Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a β-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.

AB - Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a β-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.

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U2 - 10.1039/d3cc01110k

DO - 10.1039/d3cc01110k

M3 - Article

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AN - SCOPUS:85153794118

SN - 1359-7345

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SP - 5753

EP - 5756

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells

Abstract

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