TY - JOUR
T1 - Nicotine metabolism in healthy smokers and patients with cardiovascular diseases
AU - Chahine, Ramez
AU - Abchee, Antoine
AU - Zalloua, Pierre
N1 - Funding Information:
This research was supported by grant from the Lebanese National Council for Scientific Research (NCSR) and Lebanese University. We are grateful to Dr. H. Shbaklo for the helpful assistance in the preparation of the manuscript and Mrs A. Kury for her excellent technical support.
PY - 2005/12
Y1 - 2005/12
N2 - In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine samples were collected in the morning, before smoking two cigarettes, and then three times after smoking, approximately 4 h apart. The results show that (i) in healthy smokers, nicotine and its two major metabolites were present at high concentration in the first urine sample after smoking, (ii) in smokers with cardiovascular disease nicotine and cotinine were less excreted whereas THOC was more excreted, mainly in the second urine sample. We conclude that this shift in nicotine metabolism may contribute to smoking-induced cardiovascular disease.
AB - In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine samples were collected in the morning, before smoking two cigarettes, and then three times after smoking, approximately 4 h apart. The results show that (i) in healthy smokers, nicotine and its two major metabolites were present at high concentration in the first urine sample after smoking, (ii) in smokers with cardiovascular disease nicotine and cotinine were less excreted whereas THOC was more excreted, mainly in the second urine sample. We conclude that this shift in nicotine metabolism may contribute to smoking-induced cardiovascular disease.
KW - Cardiovascular diseases
KW - Cotinine
KW - Nicotine
KW - Smoking
KW - Trans-3′-hydroxycotinine
KW - Urine
UR - https://www.scopus.com/pages/publications/29244438512
U2 - 10.1007/s11010-005-8840-9
DO - 10.1007/s11010-005-8840-9
M3 - Article
C2 - 16311929
AN - SCOPUS:29244438512
SN - 0300-8177
VL - 280
SP - 241
EP - 244
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 1-2
ER -
