Natriuretic response to direct renal interstitial volume expansion (DRIVE) in pregnant rats

Tianzheng Yu, Ali A. Khraibi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Basal renal interstitial hydrostatic pressure (RIHP) is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. The RIHP responses to increases in renal perfusion pressure (RPP) and acute saline volume expansion (VE) are attenuated in pregnant rats. Pressure natriuresis and diuresis responses are significantly attenuated during normal pregnancy, whereas the natriuretic and diuretic responses to VE remain intact. Methods: The objectives of this study were to use direct renal interstitial volume expansion (DRIVE) to selectively increase RIHP and determine the renal interstitial compliance and the relationship between RIHP, natriuretic, and diuretic responses in nonpregnant (NP; n = 8), midterm pregnant (MP; n = 8), and late-term pregnant (LP; n = 8) Sprague-Dawley (SD) rats. Results: DRIVE resulted in significant increases in RIHP, fractional excretion of sodium (FENa), and urine flow rate (V) in all groups of rats. The increase in RIHP (ΔIHP) was greatest for NP (3.3 ± 0.2 mm Hg) as compared to MP (1.3 ± 0.1 mm Hg; P < .05 v NP) and LP (1.4 ± 0.2 mm Hg; P < .05 v NP) in response to DRIVE showing that renal interstitial compliance was greater in MP and LP as compared to the NP group of rats. The increase in fractional excretion of sodium (ΔFENa) was similar in NP (3.1% ± 0.3%) and LP (3.6% ± 0.8%), but was significantly lower in MP (1.5% ± 0.4%; P < .05 v NP and LP) in response to DRIVE. Conclusions: These data suggest that the blunted increase in RIHP and natriuresis in response to DRIVE in midterm pregnant rats may play an important role in the gradual plasma volume expansion that is occurring during this stage of pregnancy.

Original languageBritish English
Pages (from-to)851-857
Number of pages7
JournalAmerican Journal of Hypertension
Issue number6
StatePublished - Jun 2005


  • Direct renal interstitial volume expansion
  • Natriuretic sensitivity
  • Pregnant rats
  • Renal interstitial compliance
  • Renal interstitial hydrostatic pressure


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