@article{cec1fd30836e4b3d939faf983a13e028,
title = "Nanostructured Fibrous Membranes with Rose Spike-Like Architecture",
abstract = "Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.",
keywords = "antimicrobial, Branched tetrapod nanoparticles, electrospinning, nanocomposites, scaffolds, zinc oxide",
author = "Amir Nasajpour and Serena Mandla and Sindu Shree and Ebrahim Mostafavi and Roholah Sharifi and Akbar Khalilpour and Saghi Saghazadeh and Shabir Hassan and Mitchell, {Michael J.} and Jeroen Leijten and Xu Hou and Alireza Moshaverinia and Nasim Annabi and Rainer Adelung and Mishra, {Yogendra Kumar} and Shin, {Su Ryon} and Ali Tamayol and Ali Khademhosseini",
note = "Funding Information: The authors gratefully acknowledge the financial support from the Presidential Early Career Award for Scientists and Engineers (PECASE), and Air Force Office of Sponsored Research under award # FA9550-15-1-0273 and the National Institutes of Health (AR066193, AR066193, EB022403, AR057837, HL137193, EB021857, EB024403). M.J.M. was supported by a Burroughs Wellcome Fund Career Award at the Scientific Interface, a NIH F32 fellowship (award number CA200351), and a grant from the Burroughs Wellcome Fund (no. 1015145). Kiel University authors acknowledge the financial support from Deutsche Forschungsgemeinshaft (DFG) under schemes AD/183/10-1 and under GRK 2154, Project P3. N.A. acknowledges the support from the American Heart Association (AHA, 16SDG31280010), FY17 TIER 1 Interdisciplinary Research Seed Grants from Northeastern University, and the startup fund provided by the Department of Chemical Engineering, College of Engineering at Northeastern University. A.N. would like to acknowledge Dr. Anas Chalah (Harvard SEAS). X.H. acknowledges the National Natural Science Foundation of China (grant 21673197) and Young Overseas High-level Talents Introduction Plan. S.H. acknowledges funding from SNSF, Switzerland. S.R.S. would like to recognize and thank Brigham and Women{\textquoteright}s Hospital President Betsy Nabel, MD, and the Reny family, for the Stepping Strong Innovator Award through their generous funding. S.S acknowledges financial support from Henri Benedictus postdoctoral fellowship from Belgian American Educational Foundation (BAEF) and King Baudouin Foundation (KBF). J.L. acknowledges financial support from Innovative Research Incentives Scheme (Veni, #14328) from the Netherlands Organization for Scientific Research (NWO). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = oct,
day = "11",
doi = "10.1021/acs.nanolett.7b02929",
language = "British English",
volume = "17",
pages = "6235--6240",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "10",
}