@inbook{4dc35a92454c4611a1e6ec5baba09045,
title = "Nanoplasmonic and microfluidic devices for biological sensing",
abstract = "In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.",
author = "G. Perozziello and A. Giugni and M. Allione and B. Torre and G. Das and Coluccio, {M. L.} and M. Marini and L. Tirinato and M. Moretti and T. Limongi and P. Candeloro and {Di Fabrizio}, Enzo",
note = "Funding Information: We thank for the financial support the King Abdullah University of Science and Technology start-up fund and the Italian Minister of Health (projects nos. GR-2010-2320665 and GR-2010-2311677) Publisher Copyright: {\textcopyright} Springer Science+Business Media Dordrecht 2017.",
year = "2017",
doi = "10.1007/978-94-024-0850-8_12",
language = "British English",
series = "NATO Science for Peace and Security Series B: Physics and Biophysics",
publisher = "Springer Verlag",
pages = "247--274",
booktitle = "NATO Science for Peace and Security Series B",
address = "Germany",
}