Nanohybrids near-field optical microscopy: From image shift to biosensor application

Nayla El-Kork, Paul Moretti, Bernard Jacquier, Feiran Lei, Mohammed Ismail

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Near-Field Optical Microscopy is a valuable tool for the optical and topographic study of objects at a nanometric scale. Nanoparticles constitute important candidates for such type of investigations, as they bear an important weight for medical, biomedical, and biosensing applications. One, however, has to be careful as artifacts can be easily reproduced. In this study, we examined hybrid nanoparticles (or nanohybrids) in the near-field, while in solution and attached to gold nanoplots. We found out that they can be used for wavelength modulable near-field biosensors within conditions of artifact free imaging. In detail, we refer to the use of topographic/optical image shift and the imaging of Local Surface Plasmon hot spots to validate the genuineness of the obtained images. In summary, this study demonstrates a new way of using simple easily achievable comparative methods to prove the authenticity of near-field images and presents nanohybrid biosensors as an application.

Original languageBritish English
Article number4089260
JournalJournal of Nanomaterials
StatePublished - 2016


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