Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

A. Bahadur, A. Saeed, M. Shoaib, S. Iqbal, S. Anwer

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

To reduce cost and increase environmental friendliness, waterborne polyurethane (WPU) is a tempting choice in the field of green chemistry. Biodegradable WPU was synthesized using lysine as an internal emulsifier. WPU was further modified using methylate methacrylate (MMA) as an acrylic monomer. Unsaturated pre-PU was synthesized by using unsaturated end-capping agent 2-hydroxyethyl methacrylate and further extended by MMA to form acrylate modified WPU. A permanent covalent linkage was established between WPU and PMMA as confirmed by FTIR spectroscopy. The focus of this research work was to study the dependence of drug delivery, mechanical, thermal, surface, and structural properties of WPU, on the MMA repeating unit content (10%–40%). For drug release studies mitomycin c was taken as a model anticancer drug. Furthermore, these materials were subjected to in vitro and in vivo cytotoxicity evaluation, which shows that synthesized acrylate modified WPU are biocompatible.

Original languageBritish English
Article number47253
JournalJournal of Applied Polymer Science
Volume136
Issue number13
DOIs
StatePublished - 5 Apr 2019

Keywords

  • biocompatible
  • eco-friendly
  • methyl methacrylate
  • mitomycin c
  • polyurethane–acrylate
  • sustained release

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