Model-based comparison of cell density-dependent cell migration strategies

H. Hatzikirou, K. Böttger, A. Deutsch

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Here, we investigate different cell density-dependent migration strategies. In particular, we consider strategies which differ in the precise regulation of transitions between resting and motile phenotypes. We develop a lattice-gas cellular automaton (LGCA) model for each migration strategy. Using a mean-field approximation we quantify the corresponding spreading dynamics at the cell population level. Our results allow for the prediction of cell population spreading based on experimentally accessible single cell migration parameters.

Original languageBritish English
Pages (from-to)94-107
Number of pages14
JournalMathematical Modelling of Natural Phenomena
Volume10
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Cell migration strategies
  • Lattice-gas cellular automaton
  • Mean-field approximation
  • Non-linear diffusion
  • Spreading dynamics

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