Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives

Win Nee Phong, Pau Loke Show, Tau Chuan Ling, Joon Ching Juan, Eng Poh Ng, Jo Shu Chang

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Bio-functional proteins from microalgae have numerous biological properties with health-promoting effects. However, efficient harnessing of bio-functional proteins from microalgae is still in its infancy. One of the major obstacles that hinder the mass production of bio-functional proteins is the presence of resistant cell wall that diminishes the liberation of cell contents. As the bio-functional proteins are very sensitive to denaturation, selecting a mild disruption method to rupture the cell wall, while preserving their bioactivity and functionality, is of vital importance in downstream processing. To ensure the future development of efficient mild disruption methods for maximum recovery of bio-functional proteins from microalgae, this review provides useful information on various mild disruption approaches, current status, potential technologies that are still under development, as well as their advantages and constraints. In particular, those potential technologies that require further attention in the future (namely, explosive decompression, microfluidization, pulsed arc technology and cationic polymer coated membranes) are also discussed in this review.

Original languageBritish English
Pages (from-to)506-516
Number of pages11
JournalAlgal Research
Volume31
DOIs
StatePublished - Apr 2018

Keywords

  • Bio-functional proteins
  • Cell wall
  • Microalgae
  • Mild cell disruption

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