Mikrobiom und Autoimmunität

Translated title of the contribution: The microbiome and autoimmunity

T. Schröder, S. Ibrahim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An abundant and diverse set of commensal microbial communities covers the body’s surfaces, collectively so-called microbiome. It has a functional impact on various immune processes and modulates many health-related processes, including autoimmunity. An active site of microorganism–host interplay is the intestinal mucosa. Growing evidence has helped us to learn how a specific microbiota composition and its functionality determine the intestinal barrier function and, furthermore, modulate pro-inflammatory and anti-inflammatory immune mechanisms in remote organs. In addition, the microbial composition of the skin is important for the functionality of the skin barrier and autoimmune skin diseases. Here, we review the importance of the microbiome for the local and systemic immune system and how a disturbed microbiome–host interaction can affect the development and progression of autoimmune diseases. Understanding these associations will help to unravel new diagnostic and therapeutic approaches for those diseases.

Translated title of the contributionThe microbiome and autoimmunity
Original languageGerman
Pages (from-to)449-455
Number of pages7
JournalInternist
Volume58
Issue number5
DOIs
StatePublished - 1 May 2017

Keywords

  • Arthritis, rheumatoid
  • Autoimmune diseases, skin
  • Diabetes mellitus, type 1
  • Lupus erythematosus, systemic
  • Multiple sclerosis

Fingerprint

Dive into the research topics of 'The microbiome and autoimmunity'. Together they form a unique fingerprint.

Cite this