Microfluidic-integrated DNA nanobiosensors

M. I.Haque Ansari, Shabir Hassan, Ahsanulhaq Qurashi, Firdous Ahmad Khanday

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise control of volumes, as low as one nanolitre and the integration of various types of bioassays on a single miniaturized platform. This integration offers several favorable advantages, such as low reagent consumption, automation of sample preparation, reduction in processing time, low cost analysis, minimal handling of hazardous materials, high detection accuracy, portability and disposability. This review provides a synopsis of the most recent developments in the microfluidic-integrated biosensing field by delineating the fundamental theory of microfluidics, fabrication techniques and a detailed account of the various transduction methods that are employed. Lastly, the review discusses state-of-the-art DNA biosensors with a focus on optical DNA biosensors.

Original languageBritish English
Pages (from-to)247-260
Number of pages14
JournalBiosensors and Bioelectronics
Volume85
DOIs
StatePublished - 15 Nov 2016

Keywords

  • Aptamer
  • Biosensors
  • DNA
  • Microfluidics
  • Nanobiosensors
  • Plasmonic

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