Microfluidic fabrication using cyclic olefin copolymer and hydrocarbon solvents

Abdulrahman Agha, Fadi Dawaymeh, Nahla Alamoodi, Eiyad Abu-Nada, Anas Alazzam

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    Cyclic olefin copolymer (COC) is a promising material in microfluidic applications due to their unique physical, chemical, and optical properties. This study implements a new and versatile fabrication process to fabricate COC microchannels, combining the fabrication and bonding processes in a single step, taking advantage of COCs’ swelling behavior in linear non-polar hydrocarbon solvents and their chemical compatibility with photolithography. Dodecane was selected as the hydrocarbon solvent based on the degree of swelling and Flory-Huggins interaction parameter, which resulted in the highest degree of swelling and affinity to COC. The effect of dodecane immersion time on the COC microchannel height was investigated, achieving a maximum average height of 50 ± 3 µm after 180 min. Bonding quality was quantified by a leakage test (maximum flow rate of 1730 ± 205 µL/min (Re = 237)), and a tensile test (800 ± 90 kPa). Furthermore, the effectiveness of the implemented process was demonstrated through the successful execution of three highly diverse microfluidic applications. These applications included a serpentine microchannel featuring semicircular obstacles that facilitated passive mixing, pinched flow fractionation which enabled the separation of a system of three different sizes of microparticles, and droplet microfluidics that allowed for the efficient generation of water in oil droplets.

    Original languageBritish English
    Article number112329
    JournalEuropean Polymer Journal
    Volume196
    DOIs
    StatePublished - 11 Sep 2023

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