Metal/metal oxide nanocomposites for bactericidal effect: A review

Rekha Pachaiappan, Saravanan Rajendran, Pau Loke Show, Kovendhan Manavalan, Mu Naushad

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Many microbial species causing infectious disease all over the world became a social burden and creating threat among community. These microbes possess long lifetime, enhancing mortality and morbidity rate in affected organisms. In this condition, the treatment was ineffective and more chances of spreading of infection into other organisms. Hence, it is necessary to initiate infection control efforts and prevention activities against multidrug resistant microbes, to reduce the death rate of people. Seriously concerning towards this problem progress was shown in developing significant drugs with least side effects. Emergence of nanoparticles and its novelty showed effective role in targeting and destructing microbes well. Further, many research works have shown nanocomposites developed from nanoparticles coupled with other nanoparticles, polymers, carbon material acted as an exotic substance against microbes causing severe loss. However, metal and metal oxide nanocomposites have gained interest due to its small size and enhancing the surface contact with bacteria, producing damage to it. The bactericidal mechanism of metal and metal oxide nanocomposites involve in the production of reactive oxygen species which includes superoxide radical anions, hydrogen peroxide anions and hydrogen peroxide which interact with the cell wall of bacteria causing damage to the cell membrane in turn inhibiting the further growth of cell with leakage of internal cellular components, leading to death of bacteria. This review provides the detailed view on antibacterial activity of metal and metal oxide nanocomposite which possessed novelty due to its physiochemical changes.

Original languageBritish English
Article number128607
StatePublished - Jun 2021


  • Antibacterial activity
  • Metal ions release
  • Metal nanocomposite
  • Metal oxide nanocomposite
  • Reactive oxygen species
  • Silver nanoparticle


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