TY - JOUR
T1 - Metal/metal oxide nanocomposites for bactericidal effect
T2 - A review
AU - Pachaiappan, Rekha
AU - Rajendran, Saravanan
AU - Show, Pau Loke
AU - Manavalan, Kovendhan
AU - Naushad, Mu
N1 - Funding Information:
The authors (S.R) acknowledge the support of ANID through the project FONDAP (Project No.: 15110019) and FONDECYT (Project No.: 11170414 ) for the support to carry out this project. The author (K.M) thanks the Science & Engineering Research Board ( SERB ), Department of Science and Technology, Government of India , for the National Post Doctoral Fellowship (File Number: PDF/2019/002766 ), Fundamental Research Grant Scheme, Malaysia [ FRGS/1/2019/STG05/UNIM/02/2 ], and MyPAIR-PHC-Hibiscus Grant [ MyPAIR/1/2020/STG05/UNIM/1 ]. All the authors are thankful to biorender.com for preparation of the images.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - Many microbial species causing infectious disease all over the world became a social burden and creating threat among community. These microbes possess long lifetime, enhancing mortality and morbidity rate in affected organisms. In this condition, the treatment was ineffective and more chances of spreading of infection into other organisms. Hence, it is necessary to initiate infection control efforts and prevention activities against multidrug resistant microbes, to reduce the death rate of people. Seriously concerning towards this problem progress was shown in developing significant drugs with least side effects. Emergence of nanoparticles and its novelty showed effective role in targeting and destructing microbes well. Further, many research works have shown nanocomposites developed from nanoparticles coupled with other nanoparticles, polymers, carbon material acted as an exotic substance against microbes causing severe loss. However, metal and metal oxide nanocomposites have gained interest due to its small size and enhancing the surface contact with bacteria, producing damage to it. The bactericidal mechanism of metal and metal oxide nanocomposites involve in the production of reactive oxygen species which includes superoxide radical anions, hydrogen peroxide anions and hydrogen peroxide which interact with the cell wall of bacteria causing damage to the cell membrane in turn inhibiting the further growth of cell with leakage of internal cellular components, leading to death of bacteria. This review provides the detailed view on antibacterial activity of metal and metal oxide nanocomposite which possessed novelty due to its physiochemical changes.
AB - Many microbial species causing infectious disease all over the world became a social burden and creating threat among community. These microbes possess long lifetime, enhancing mortality and morbidity rate in affected organisms. In this condition, the treatment was ineffective and more chances of spreading of infection into other organisms. Hence, it is necessary to initiate infection control efforts and prevention activities against multidrug resistant microbes, to reduce the death rate of people. Seriously concerning towards this problem progress was shown in developing significant drugs with least side effects. Emergence of nanoparticles and its novelty showed effective role in targeting and destructing microbes well. Further, many research works have shown nanocomposites developed from nanoparticles coupled with other nanoparticles, polymers, carbon material acted as an exotic substance against microbes causing severe loss. However, metal and metal oxide nanocomposites have gained interest due to its small size and enhancing the surface contact with bacteria, producing damage to it. The bactericidal mechanism of metal and metal oxide nanocomposites involve in the production of reactive oxygen species which includes superoxide radical anions, hydrogen peroxide anions and hydrogen peroxide which interact with the cell wall of bacteria causing damage to the cell membrane in turn inhibiting the further growth of cell with leakage of internal cellular components, leading to death of bacteria. This review provides the detailed view on antibacterial activity of metal and metal oxide nanocomposite which possessed novelty due to its physiochemical changes.
KW - Antibacterial activity
KW - Metal ions release
KW - Metal nanocomposite
KW - Metal oxide nanocomposite
KW - Reactive oxygen species
KW - Silver nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85093654090&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2020.128607
DO - 10.1016/j.chemosphere.2020.128607
M3 - Article
C2 - 33097236
AN - SCOPUS:85093654090
SN - 0045-6535
VL - 272
JO - Chemosphere
JF - Chemosphere
M1 - 128607
ER -