Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Phoebe K. Allan; Paul S. Wheatley; David Aldous; M. Infas Mohideen; Chiu Tang; Joseph A. Hriljac; Ian L. Megson; Karena W. Chapman; Guy De Weireld; Sebastian Vaesen; Russell E. Morris

doi:10.1039/c2dt12069k

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Phoebe K. Allan, Paul S. Wheatley, David Aldous, M. Infas Mohideen, Chiu Tang, Joseph A. Hriljac, Ian L. Megson, Karena W. Chapman, Guy De Weireld, Sebastian Vaesen, Russell E. Morris

Chemistry

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

Original language	British English
Pages (from-to)	4060-4066
Number of pages	7
Journal	Dalton Transactions
Volume	41
Issue number	14
DOIs	https://doi.org/10.1039/c2dt12069k
State	Published - 14 Apr 2012

Access to Document

10.1039/c2dt12069k

Cite this

@article{8f1e64c7d0384d349fed90b53cf3f1a8,

title = "Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide",

abstract = "Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.",

author = "Allan, {Phoebe K.} and Wheatley, {Paul S.} and David Aldous and Mohideen, {M. Infas} and Chiu Tang and Hriljac, {Joseph A.} and Megson, {Ian L.} and Chapman, {Karena W.} and {De Weireld}, Guy and Sebastian Vaesen and Morris, {Russell E.}",

year = "2012",

month = apr,

day = "14",

doi = "10.1039/c2dt12069k",

language = "British English",

volume = "41",

pages = "4060--4066",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "14",

}

TY - JOUR

T1 - Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

AU - Allan, Phoebe K.

AU - Wheatley, Paul S.

AU - Aldous, David

AU - Mohideen, M. Infas

AU - Tang, Chiu

AU - Hriljac, Joseph A.

AU - Megson, Ian L.

AU - Chapman, Karena W.

AU - De Weireld, Guy

AU - Vaesen, Sebastian

AU - Morris, Russell E.

PY - 2012/4/14

Y1 - 2012/4/14

N2 - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

AB - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

UR - http://www.scopus.com/inward/record.url?scp=84858736071&partnerID=8YFLogxK

U2 - 10.1039/c2dt12069k

DO - 10.1039/c2dt12069k

M3 - Article

C2 - 22378060

AN - SCOPUS:84858736071

SN - 1477-9226

VL - 41

SP - 4060

EP - 4066

JO - Dalton Transactions

JF - Dalton Transactions

IS - 14

ER -

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Abstract

Access to Document

Other files and links

Fingerprint

Cite this