Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies

Wissam H. Faour; Ali Choaib; Elio Issa; Francesca El Choueiry; Khodor Shbaklo; Maryline Alhajj; Ramy Touma Sawaya; Zeina Harhous; Eman Alefishat; Moni Nader

doi:10.1007/s00011-021-01520-8

Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies

Wissam H. Faour, Ali Choaib, Elio Issa, Francesca El Choueiry, Khodor Shbaklo, Maryline Alhajj, Ramy Touma Sawaya, Zeina Harhous, Eman Alefishat, Moni Nader

College of Medicine and Health Sciences

Lebanese American University

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.

Original language	British English
Pages (from-to)	39-56
Number of pages	18
Journal	Inflammation Research
Volume	71
Issue number	1
DOIs	https://doi.org/10.1007/s00011-021-01520-8
State	Published - Jan 2022

Keywords

Angiotensin
COVID-19
Inflammation
Kidney
Renal pathology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00011-021-01520-8

Cite this

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abstract = "The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.",

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AU - Faour, Wissam H.

AU - Choaib, Ali

AU - Issa, Elio

AU - Choueiry, Francesca El

AU - Shbaklo, Khodor

AU - Alhajj, Maryline

AU - Sawaya, Ramy Touma

AU - Harhous, Zeina

AU - Alefishat, Eman

AU - Nader, Moni

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N2 - The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.

AB - The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.

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KW - COVID-19

KW - Inflammation

KW - Kidney

KW - Renal pathology

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Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies

Abstract

Keywords

UN SDGs

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