Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Rupesh Dash; Sujit K. Bhutia; Belal Azab; Zhao zhong Su; Bridget A. Quinn; Timothy P. Kegelmen; Swadesh K. Das; Keetae Kim; Seok Geun Lee; Margaret A. Park; Adly Yacoub; Mohammed Rahmani; Luni Emdad; Igor P. Dmitriev; Xiang Yang Wang; Devanand Sarkar; Steven Grant; Paul Dent; David T. Curiel; Paul B. Fisher

doi:10.1016/j.cytogfr.2010.08.004

Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Rupesh Dash
, Sujit K. Bhutia
, Belal Azab
, Zhao zhong Su
, Bridget A. Quinn
, Timothy P. Kegelmen
, Swadesh K. Das
, Keetae Kim
, Seok Geun Lee
, Margaret A. Park
, Adly Yacoub
, Mohammed Rahmani
, Luni Emdad
, Igor P. Dmitriev
, Xiang Yang Wang
, Devanand Sarkar
, Steven Grant
, Paul Dent
, David T. Curiel
, Paul B. Fisher

College of Medicine and Health Sciences

Virginia Commonwealth University
Icahn School of Medicine at Mount Sinai
Virginia Commonwealth University Health System
Kyung Hee University
Virginia Commonwealth University
University of Alabama in Birmingham

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.

Original language	British English
Pages (from-to)	381-391
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.cytogfr.2010.08.004
State	Published - Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Autophagy
Bystander antitumor activity
Cancer terminator virus
Mda-7/IL-24

Access to Document

10.1016/j.cytogfr.2010.08.004

OpenUrl availability

Full text

Cite this

Dash, R., Bhutia, S. K., Azab, B., Su, Z. Z., Quinn, B. A., Kegelmen, T. P., Das, S. K., Kim, K., Lee, S. G., Park, M. A., Yacoub, A., Rahmani, M., Emdad, L., Dmitriev, I. P., Wang, X. Y., Sarkar, D., Grant, S., Dent, P., Curiel, D. T., & Fisher, P. B. (2010). Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity. Cytokine and Growth Factor Reviews, 21(5), 381-391. https://doi.org/10.1016/j.cytogfr.2010.08.004

@article{49a21c4efb7348c5b6194769dd633b1e,

title = "Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity",

abstract = "Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.",

keywords = "Apoptosis, Autophagy, Bystander antitumor activity, Cancer terminator virus, Mda-7/IL-24",

author = "Rupesh Dash and Bhutia, \{Sujit K.\} and Belal Azab and Su, \{Zhao zhong\} and Quinn, \{Bridget A.\} and Kegelmen, \{Timothy P.\} and Das, \{Swadesh K.\} and Keetae Kim and Lee, \{Seok Geun\} and Park, \{Margaret A.\} and Adly Yacoub and Mohammed Rahmani and Luni Emdad and Dmitriev, \{Igor P.\} and Wang, \{Xiang Yang\} and Devanand Sarkar and Steven Grant and Paul Dent and Curiel, \{David T.\} and Fisher, \{Paul B.\}",

note = "Funding Information: The present research was supported in part by National Institutes of Health Grants R01 CA097318 , R01 CA127641 , R01 CA108520 , P01 CA104177 , and the National Foundation for Cancer Research . DS is a Harrison Scholar in Cancer Research and PBF holds the Thelma Newmeyer Corman Chair in Cancer Research in the Massey Cancer Center. ",

year = "2010",

month = oct,

doi = "10.1016/j.cytogfr.2010.08.004",

language = "British English",

volume = "21",

pages = "381--391",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier Ltd",

number = "5",

}

Dash, R, Bhutia, SK, Azab, B, Su, ZZ, Quinn, BA, Kegelmen, TP, Das, SK, Kim, K, Lee, SG, Park, MA, Yacoub, A, Rahmani, M, Emdad, L, Dmitriev, IP, Wang, XY, Sarkar, D, Grant, S, Dent, P, Curiel, DT & Fisher, PB 2010, 'Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity', Cytokine and Growth Factor Reviews, vol. 21, no. 5, pp. 381-391. https://doi.org/10.1016/j.cytogfr.2010.08.004

TY - JOUR

T1 - Mda-7/IL-24

T2 - A unique member of the IL-10 gene family promoting cancer-targeted toxicity

AU - Dash, Rupesh

AU - Bhutia, Sujit K.

AU - Azab, Belal

AU - Su, Zhao zhong

AU - Quinn, Bridget A.

AU - Kegelmen, Timothy P.

AU - Das, Swadesh K.

AU - Kim, Keetae

AU - Lee, Seok Geun

AU - Park, Margaret A.

AU - Yacoub, Adly

AU - Rahmani, Mohammed

AU - Emdad, Luni

AU - Dmitriev, Igor P.

AU - Wang, Xiang Yang

AU - Sarkar, Devanand

AU - Grant, Steven

AU - Dent, Paul

AU - Curiel, David T.

AU - Fisher, Paul B.

N1 - Funding Information: The present research was supported in part by National Institutes of Health Grants R01 CA097318 , R01 CA127641 , R01 CA108520 , P01 CA104177 , and the National Foundation for Cancer Research . DS is a Harrison Scholar in Cancer Research and PBF holds the Thelma Newmeyer Corman Chair in Cancer Research in the Massey Cancer Center.

PY - 2010/10

Y1 - 2010/10

N2 - Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.

AB - Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.

KW - Apoptosis

KW - Autophagy

KW - Bystander antitumor activity

KW - Cancer terminator virus

KW - Mda-7/IL-24

UR - https://www.scopus.com/pages/publications/78649725645

U2 - 10.1016/j.cytogfr.2010.08.004

DO - 10.1016/j.cytogfr.2010.08.004

M3 - Article

C2 - 20926331

AN - SCOPUS:78649725645

SN - 1359-6101

VL - 21

SP - 381

EP - 391

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 5

ER -

Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Abstract

UN SDGs

Keywords

Access to Document

OpenUrl availability

Other files and links

Fingerprint

Cite this