Manipulation of herpes simplex virus type 1 by dielectrophoresis

Michael P. Hughes, Hywel Morgan, Frazer J. Rixon, Julian P.H. Burt, Ronald Pethig

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

The frequency-dependent dielectrophoretic behaviour of an enveloped mammalian virus, herpes simplex virus type 1 is described. It is demonstrated that over the range 10 kHz-20 MHz, these viral particles, when suspended in an aqueous medium of conductivity 5 mS m-1, can be manipulated by both positive and negative dielectrophoresis using microfabricated electrode arrays. The observed transition from positive to negative dielectrophoresis at frequencies around 4.5 MHz is in qualitative agreement with a simple model of the virus as a conducting particle surrounded by an insulating membrane. Copyright (C) 1998 Elsevier Science B.V.

Original languageBritish English
Pages (from-to)119-126
Number of pages8
JournalBBA - General Subjects
Volume1425
Issue number1
DOIs
StatePublished - 16 Sep 1998

Keywords

  • AC electrokinetics
  • Dielectric property
  • Nanotechnology
  • Particle manipulation

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