TY - JOUR
T1 - Magnetic metal-organic frameworks immobilized enzyme-based nano-biocatalytic systems for sustainable biotechnology
AU - Bilal, Muhammad
AU - Rashid, Ehsan Ullah
AU - Munawar, Junaid
AU - Iqbal, Hafiz M.N.
AU - Cui, Jiandong
AU - Zdarta, Jakub
AU - Ashraf, Syed Salman
AU - Jesionowski, Teofil
N1 - Funding Information:
The research leading to these results has received funding from the Norwegian Financial Mechanism 2014–2021 under Project number 2020/37/K/ST8/03805 . Khalifa University is graciously acknowledged for supporting this work under the international collaboration project awarded to Syed Salman Ashraf and Muhammad Bilal ( CIRA-2020-046 ).
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/5/15
Y1 - 2023/5/15
N2 - Nanobiocatalysts, in which enzyme molecules are integrated into/onto multifunctional materials, such as metal-organic frameworks (MOFs), have been fascinating and appeared as a new interface of nanobiocatalysis with multi-oriented applications. Among various nano-support matrices, functionalized MOFs with magnetic attributes have gained supreme interest as versatile nano-biocatalytic systems for organic bio-transformations. From the design (fabrication) to deployment (application), magnetic MOFs have manifested notable efficacy in manipulating the enzyme microenvironment for robust biocatalysis and thus assure requisite applications in several areas of enzyme engineering at large and nano-biocatalytic transformations, in particular. Magnetic MOFs-linked enzyme-based nano-biocatalytic systems offer chemo-regio- and stereo-selectivities, specificities, and resistivities under fine-tuned enzyme microenvironments. Considering the current sustainable bioprocesses demands and green chemistry needs, we reviewed synthesis chemistry and application prospects of magnetic MOFs-immobilized enzyme-based nano-biocatalytic systems for exploitability in different industrial and biotechnological sectors. More specifically, following a thorough introductory background, the first half of the review discusses various approaches to effectively developed magnetic MOFs. The second half mainly focuses on MOFs-assisted biocatalytic transformation applications, including biodegradation of phenolic compounds, removal of endocrine disrupting compounds, dye decolorization, green biosynthesis of sweeteners, biodiesel production, detection of herbicides and screening of ligands and inhibitors.
AB - Nanobiocatalysts, in which enzyme molecules are integrated into/onto multifunctional materials, such as metal-organic frameworks (MOFs), have been fascinating and appeared as a new interface of nanobiocatalysis with multi-oriented applications. Among various nano-support matrices, functionalized MOFs with magnetic attributes have gained supreme interest as versatile nano-biocatalytic systems for organic bio-transformations. From the design (fabrication) to deployment (application), magnetic MOFs have manifested notable efficacy in manipulating the enzyme microenvironment for robust biocatalysis and thus assure requisite applications in several areas of enzyme engineering at large and nano-biocatalytic transformations, in particular. Magnetic MOFs-linked enzyme-based nano-biocatalytic systems offer chemo-regio- and stereo-selectivities, specificities, and resistivities under fine-tuned enzyme microenvironments. Considering the current sustainable bioprocesses demands and green chemistry needs, we reviewed synthesis chemistry and application prospects of magnetic MOFs-immobilized enzyme-based nano-biocatalytic systems for exploitability in different industrial and biotechnological sectors. More specifically, following a thorough introductory background, the first half of the review discusses various approaches to effectively developed magnetic MOFs. The second half mainly focuses on MOFs-assisted biocatalytic transformation applications, including biodegradation of phenolic compounds, removal of endocrine disrupting compounds, dye decolorization, green biosynthesis of sweeteners, biodiesel production, detection of herbicides and screening of ligands and inhibitors.
KW - Biotransformation
KW - Enzyme immobilization
KW - Magnetic materials
KW - MOFs
KW - Nanobiocatalysis
UR - http://www.scopus.com/inward/record.url?scp=85150937521&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2023.123968
DO - 10.1016/j.ijbiomac.2023.123968
M3 - Review article
C2 - 36906204
AN - SCOPUS:85150937521
SN - 0141-8130
VL - 237
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 123968
ER -