Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation

Upendar Reddy Gandra; Batakrishna Jana; Patrick Hammer; M. Infas H. Mohideen; Ute Neugebauer; Alexander Schiller

doi:10.1039/d4cc00009a

Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation

Upendar Reddy Gandra, Batakrishna Jana, Patrick Hammer, M. Infas H. Mohideen, Ute Neugebauer, Alexander Schiller

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report a specific lysosome targeted light-responsive CO-releasing molecule (Lyso-CORM). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen (¹O₂) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that Lyso-CORM showed good phototoxicity due to the synergistic effect of CO and ¹O₂ release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make Lyso-CORM a potent candidate for phototherapeutic applications.

Original language	British English
Pages (from-to)	2098-2101
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	15
DOIs	https://doi.org/10.1039/d4cc00009a
State	Published - 23 Jan 2024

Access to Document

10.1039/d4cc00009a

Cite this

@article{bc5ede93473f455b9e50f23b21cbe852,

title = "Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation",

abstract = "We report a specific lysosome targeted light-responsive CO-releasing molecule (Lyso-CORM). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen (1O2) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that Lyso-CORM showed good phototoxicity due to the synergistic effect of CO and 1O2 release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make Lyso-CORM a potent candidate for phototherapeutic applications.",

author = "Gandra, {Upendar Reddy} and Batakrishna Jana and Patrick Hammer and Mohideen, {M. Infas H.} and Ute Neugebauer and Alexander Schiller",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2024",

month = jan,

day = "23",

doi = "10.1039/d4cc00009a",

language = "British English",

volume = "60",

pages = "2098--2101",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation

AU - Gandra, Upendar Reddy

AU - Jana, Batakrishna

AU - Hammer, Patrick

AU - Mohideen, M. Infas H.

AU - Neugebauer, Ute

AU - Schiller, Alexander

PY - 2024/1/23

Y1 - 2024/1/23

N2 - We report a specific lysosome targeted light-responsive CO-releasing molecule (Lyso-CORM). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen (1O2) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that Lyso-CORM showed good phototoxicity due to the synergistic effect of CO and 1O2 release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make Lyso-CORM a potent candidate for phototherapeutic applications.

AB - We report a specific lysosome targeted light-responsive CO-releasing molecule (Lyso-CORM). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen (1O2) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that Lyso-CORM showed good phototoxicity due to the synergistic effect of CO and 1O2 release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make Lyso-CORM a potent candidate for phototherapeutic applications.

UR - http://www.scopus.com/inward/record.url?scp=85184021725&partnerID=8YFLogxK

U2 - 10.1039/d4cc00009a

DO - 10.1039/d4cc00009a

M3 - Article

C2 - 38295368

AN - SCOPUS:85184021725

SN - 1359-7345

VL - 60

SP - 2098

EP - 2101

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this