Loss of neurones after long-term adrenalectomy in the adult rat hippocampal formation

Abdu Adem, Atiqul Islam, Nenad Bogdanovic, Kjell Carlstrom, Bengt Winblad

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22 Scopus citations

Abstract

The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of tne hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.

Original languageBritish English
Pages (from-to)2285-2288
Number of pages4
JournalNeuroReport
Volume5
Issue number17
DOIs
StatePublished - Nov 1994

Keywords

  • Adrenalectomy
  • Dentate gyrus
  • Hippocampus
  • Neuronal degeneration
  • Pyramidal cells

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